Description
TES is a tumor suppressor protein and may play role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. This protein localizes to cell-cell contacts and actin stress fibres, and interacts with a variety of cytoskeletal proteins including Zyxin, Mena, VASP, Talin and Actin. The ability of TES to associate with alpha-actinin, paxillin and Zyxin is dependent on the conformational state of the molecule. Recombinant human TES protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques